In cultures with left-right-script, agentic behavior is mentally represented as following a left-to-right trajectory, an effect referred to as the Spatial Agency Bias. In this research, we investigated whether spatial representations of activities are universal across activities by analyzing the opposite concepts of “attack” and “defense”. Both behaviors involve similar actions but may differ in perceived agency. Moreover “defense” is necessarily always a response to an attack and may therefore be represented by a trajectory in the opposite direction. Two studies (...) found the classic SAB for activities representing attacking but a reduction and reversal for activities involving defense. Although the spatial representation of defense on the right was much weaker and less unequivocal than that of attack on the left, the results suggest that the spatial representations of defense and attack are located in different positions. Apparently not all actors and all activities are spatially represented on the left with a left-to-right trajectory but position and direction depend on the perceived agency. Directions for future research and applications of our findings are discussed. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Decision outcomes sometimes result in negative emotions. This can occur when a decision appears to be wrong in retrospect, and/or when the obtained decision outcome does not live up to expectations. Regret and disappointment are the two emotions that are of central interest in the present article. Although these emotions have a lot in common, they also differ in ways that are relevant to decision making. In this article we review theories and empirical findings concerning regret and disappointment. We first (...) discuss how regret and disappointment differ with respect to their antecedent conditions, appraisals, and phenomenology. We also discuss possible behavioural consequences of experiencing these emotions. Next, we consider how the anticipation of regret and disappointment may influence decision making. We use regret and disappointment theory, developed by the economists Bell (1982, 1985), and Loomes and Sugden (1982, 1986, 1987), as a framework for our discussion. Finally, we argue that combining the theoretical approaches and research paradigms of behavioural decision theory with emotion theories will significantly increase our knowledge of antecedents and consequences of emotions. (shrink)

Since the February 2020 publication of the article ‘Flattening the curve’ in The Economist, political leaders worldwide have used this expression to legitimize the introduction of social distancing measures in fighting Covid-19. In fact, this expression represents a complex combination of three components: the shape of the epidemic curve, the social distancing measures and the reproduction number \. Each component has its own history, each with a different history of control. Presenting the control of the epidemic as flattening the curve (...) is in fact flattening the underlying natural-social complexity. The curve that needs to be flattened is presented as a bell-shaped curve, implicitly suggesting that the pathogen’s spread is subject only to natural laws. The \ value, however, is, fundamentally, a metric of how a pathogen behaves within a social context, namely its numerical value is affected by sociopolitical influences. The jagged and erratic empirical curve of Covid-19 illustrates this. Although the virus has most likely infected only a small portion of the total susceptible population, it is clear its shape has changed drastically. This changing shape is largely due to sociopolitical factors. These include shifting formal laws and policies, shifting individual behaviors as well as shifting various other social norms and practices. This makes the course of Covid-19 curve both erratic and unpredictable. (shrink)

This book introduces the student to active philosophical thinking about political ideas, offering a more stimulating approach to the subject than traditional chronological surveys. The first edition was hailed by The Times Literary Supplement as 'the best introduction to political philosophy for a long time'. This thoroughly revised second edition brings its coverage up-to-date for the 1990s, with material reorganised to be fully accessible for the beginner.

The Masters of Truth in Archaic Greece traces the odyssey of "truth," Aletheia, from mythoreligious to philosophical thought in archaic Greece. Marcel Detienne's starting point is a simple observation: In archaic Greece, three figures - the diviner, the bard, and the king - all share the privilege of dispensing truth by virtue of the religious power of divine memory which provides them with knowledge, both oracular and inspired, of the present, past, and future. Beginning with this definition of the (...) prerational meaning of truth, Detienne proceeds to elaborate the complex conceptual and historical contexts from which emerges the philosophical notion of truth still influencing Western philosophy today. (shrink)

Generally, simulations are carried out to answer specific questions. The assessment of the reliability of an answer depends on the kind of question investigated. The answer to a 'why' question is an explanation. The premises of an explanation have to include invariant relationships, and thus the reliability of such answer depends on whether the domain of invariance of the relevant relationships covers the domain of the question. The answer to a 'how much' question is a measurement. A measurement is reliable (...) when it is an output of a calibrated measuring instrument. (shrink)

This volume investigates the notion of reduction. Building on the idea that philosophers employ the term ‘reduction’ to reconcile diversity and directionality with unity, without relying on elimination, the book offers a powerful explication of an “ontological” notion of reduction the extension of which is (primarily) formed by properties, kinds, individuals, or processes. It argues that related notions of reduction, such as theory-reduction and functional reduction, should be defined in terms of this explication. Thereby, the book offers a coherent framework, (...) which sheds light on the history of the various reduction debates in the philosophy of science and in the philosophy of mind, and on related topics such as reduction and unification, the notion of a scientific level, and physicalism. (shrink)

ZusammenfassungEthik-Cafés in der geriatrischen Langzeitpflege dienen auch der ethischen Weiterbildung und sollen den Beteiligten in ungezwungener Atmosphäre einen offenen Diskurs über moralische Fragen mit Bezug zum Arbeitsalltag ermöglichen. In der Literatur werden ihnen diverse Eigenschaften wie Verbesserung der Analysefähigkeit und der Kommunikation, Erhöhung der ethischen Sensibilität und der Entscheidungskompetenz und weitere zugeschrieben. Diese Eigenschaften resultieren vorwiegend aus theoriegeleiteten Modellen. Gegenstand dieser Studie ist die empirische Untersuchung der Wirksamkeit von Ethik-Cafés innerhalb der Pflegezentren Mattenhof-Irchelpark, Zürich. Des Weiteren geht die Studie der (...) Frage nach, ob sich die subjektiven Einschätzungen der Eigenschaften von Pflegenden und anderen Berufsgruppen unterscheiden. Zur Erfassung der Eigenschaften wurde ein Fragebogen konstruiert, in dem die Teilnehmenden während der Erhebungszeit 16 Aussagen zu bewerten hatten. Die Bewertung konnte mittels einer 5-stufigen Likert-Skala angegeben werden. In einer Untergruppe wurde zwischen „Pflege“ und „Nicht-Pflege“ unterschieden. Zusammenfassend konnte festgestellt werden, dass die postulierten Eigenschaften mit einer sehr hohen Zustimmung bestätigt werden. Die Ethik-Cafés leisten nach Meinung der Befragten einen wichtigen Beitrag zur Befähigung des Personals, schwierige Situationen klarer zu analysieren, ethisch sensibler zu entscheiden und die getroffene Entscheidung zu begründen. Die Interdisziplinarität der Ethik-Cafés fördert das Verständnis für die Sichtweisen und Argumentationen der verschiedenen Bereiche und Hierarchien. Die Unterschiede der Berufsgruppen sind teilweise hoch-signifikant. Es kann festgehalten werden, dass die im Fragebogen attribuierten Eigenschaften von der Pflege generell stärker und bedeutsamer wahrgenommen werden. (shrink)

Biological modalities, i.e., biologically possible, impossible, or necessary states of affairs have not received much attention from philosophers. Yet, it is widely agreed that there are biological constraints on physically possible states of affairs, such that not everything that is physically possible is also biologically possible, even if everything that is biologically possible is also physically possible. Furthermore, biologists use concepts that appear to be modal in nature, such as the concept of evolvability in evolutionary developmental biology, or “evo-devo.” The (...) present chapter investigates what kind of modality underlies the concept of evolvability. This concept tries to capture the capacity of an organism or a lineage to sustain genetic changes that enable it to evolve or to evolve adaptively. The basic idea of the proposed approach is to construe evolvability as a kind of accessibility in a modal space. The difficult part is to specify this modal space and the relevant accessibility relation. While there may not be a general way of defining such a relation, there exist model systems for which it is possible, e.g., evolving small RNAs. The modal space in such cases turns out to be quite distinct from those constructed by philosophers, e.g., David Lewis’s similarity metric for possible worlds. Even though the biological case examined here is quite special, attending to the way in which biological possibilities are modeled in this case harbors some general lessons about biological modalities, in particular their dependence on the explanatory goals of the models modeling modality. (shrink)

The concept of a sovereign nation-state is a central part in many of the debates discussing the salient issues in political science today. Yet the debate on the state is fragmented and while the sub-disciplines within political science address the various possible consequences of different processes, the one thing they all share is uncertainty about the future shape and role of the state. _Political Pluralism and the State_ is the first work in political theory to bring together IR, comparative politics (...) and political theory approaches to analyze the post-sovereign state and develop a new interpretative scheme for social and political scientists. A scheme that takes account not only of the fragmentation of the polity but also of the often ignored concurrent fragmentation of society. The book seeks to understand and interpret political pluralization as an expression of the continuous processes of cooperation and secession that define politics and legitimize institutions. It develops an alternative, sovereignty-free conception of the ‘polis’ sensitive to these unavoidable processes, and assesses the viability of liberal-democratic ideals in a radically pluralized world. This book will be of interest to students and scholars in philosophy, politics, political economy, international relations, sociology and other social sciences. (shrink)

We are encouraged by the many positive commentaries on our target article. In this response, we recapitulate some of the points raised and identify synergies between them. We have arranged our response based on the tension between data and architecture that arises in the meta-learning framework. We additionally provide a short discussion that touches upon connections to foundation models.

I examine the adequacy of the causal graph-structural equations approach to causation for modeling biological mechanisms. I focus in particular on mechanisms with complex dynamics such as the PER biological clock mechanism in Drosophila. I show that a quantitative model of this mechanism that uses coupled differential equations – the well-known Goldbeter model – cannot be adequately represented in the standard causal graph framework, even though this framework does permit causal cycles. The reason is that the model contains dynamical information (...) about the mechanism that concerns causal properties but that does not correspond to variables that could be subject to independent interventions. Thus, a representation of the mechanisms as a causal structural model necessarily suppresses causally relevant information. (shrink)

Tandis que les biens matériels sont relativement aisés à évaluer parce qu’ils sont tangibles et quantifiables, les biens immatériels (ou « intangibles ») demandent une méthode plus complexe d’évaluation. Ainsi en va-t-il des savoirs, des services, des productions de l’esprit et de la culture en général. Il existe en effet un marché de tels biens et cela depuis qu’il existe des échanges marchands. Trois opérations le permettent : l’évaluation par unités mesure, le formatage des activités, l’échange ou le partage de (...) ces biens. Mais au-delà de ces biens immatériels évaluables sur un marché, il y a des biens ou plutôt des valeurs qui ne le sont pas et ne le seront jamais ; ils ont rapport au talent, au don, à la confiance, à la dignité – bref à l’inestimable. (shrink)

In this paper I explore some connections between two anti-essentialist approaches to democratic theory — Ernesto Laclau and Chantal Mouffe's hegemonic approach and Slavoj Zizek's psychoanalytic approach. I argue that a central virtue of Laclau and Mouffe's hegemonic approach to democracy is that it clearly emphasizes the ethos of democracy, not simply the institutions of democracy. This shift transforms democracy, now conceived as radical democratic ethos, into a site of further research about how to make our understanding of its conditions (...) more theoretically nuanced. In the main bulk of the paper, I explore how Slavoj Zizek's notion of an authentic political act seeks to develop this understanding. (shrink)

Psychologists and neuroscientists extensively rely on computational models for studying and analyzing the human mind. Traditionally, such computational models have been hand-designed by expert researchers. Two prominent examples are cognitive architectures and Bayesian models of cognition. Although the former requires the specification of a fixed set of computational structures and a definition of how these structures interact with each other, the latter necessitates the commitment to a particular prior and a likelihood function that – in combination with Bayes' rule – (...) determine the model's behavior. In recent years, a new framework has established itself as a promising tool for building models of human cognition: the framework of meta-learning. In contrast to the previously mentioned model classes, meta-learned models acquire their inductive biases from experience, that is, by repeatedly interacting with an environment. However, a coherent research program around meta-learned models of cognition is still missing to date. The purpose of this article is to synthesize previous work in this field and establish such a research program. We accomplish this by pointing out that meta-learning can be used to construct Bayes-optimal learning algorithms, allowing us to draw strong connections to the rational analysis of cognition. We then discuss several advantages of the meta-learning framework over traditional methods and reexamine prior work in the context of these new insights. (shrink)

Δύο ἐπιγραφικά εὑρήματα πού δημοσιεύτηκαν πρόσφατα ἴσως μᾶς ἐπιτρέψουν νά προσδιορίσουμε σέ δύο σημεῖα τό ὁδοιπορικό πού ἀκολούθησε ὁ Παυσανίας στό Ἄργός. Τό πολιτικό κέντρο τῆς πόλης ἦταν ἐγκαταστημένο στους πρόποδες τῆς Λάρισας, κατά μῆκος του δρόμου ἀπό τήν Κόρινθο στήν Τεγέα· στό σημεῖο αὐτό συγκλίνουν οἱ δρόμοι πού ὁδηγοῦν στήν Τίρυνθα καί στήν Ἐπίδαυρο ἀφ' ἑνός, στό Ήραῖο καί στό βορειοανατολικό τμῆμα τῆς 'Αργολίδας ἀφ' ἑτέρου. Φαίνεται πώς θά πρέπει νά γυρέψουμε τήν πύλη τῆς Εἰλιθυίας ἀπό ὅπου ἔφτασε κανείς (...) στό Ήραῖο κάπου πάνω στον ἄξονα τῆς σημερινῆς ὁδοῦ Θεάτρου καί λίγο βορεινότερα. Μιά ἐπιγραφή πού θά μποροῦσε νά προέρχεται ἀπό τό ἱερό τοῦ Διονύσου καί βρέθηκε κοντά στήν ἐκκλησία τοῦ Ἁγίου Πέτρου φαίνεται νά βεβαιώνει τήν ὑπόθεση τοῦ Boethius ὅτι ἡ Κοίλη πρέπει νά ἀναζητηθεῖ σ' αὐτόν τόν τομέα. (shrink)

The aim of the paper is to reconsider the traditional evaluation of S. H. Vajanský, which underlines mainly the anti-progressive, conservative and anti-realistic features of his later writings. The examination of his earlier articles in Narodné noviny up to 1883 shows, however, his critical openness to the contributions of constitutionalism. His primordialistic standpoint is enriched by the ideas emphasizing the importance of the education of wider public as well as the necessity of polemics in creating Slovak national awareness. Young Vajanský (...) did not dismiss the incentives of liberalism or constitutionalism. He rather criticized their formalism. He acknowledged their key contribution in expanding the ideas of the freedom of press and speech, which should have served the political elites in their creating the national identity. (shrink)

RESUMO Com base na noção de currículo como uma arena de embates discursivos, este artigo tem por objetivo principal analisar de que modo a Base Nacional Comum Curricular de Língua Portuguesa e Literaturas compreende os conceitos de fruição e de leitor-fruidor. Com efeito, é nossa intenção compreender como a ideia de leitura literária é proposta por esse documento oficial curricular. Para tanto, as habilidades e conteúdos indicados pela Base Nacional Comum Curricular foram analisados a partir de uma perspectiva metodológica interpretativista (...) e sob a perspectiva dialógica de análise do discurso desenvolvida pelo Círculo de Bakhtin. ABSTRACT Based on the notion of curriculum as an arena of discursive clashes, this paper aims at verifying how the Base Nacional Comum Curricular [Common Core] for Portuguese Language and Literature understands the concepts of fruition and reader-in-fruition. Indeed, it is our intention to understand the very idea of literary reading proposed by this official curriculum document. For this purpose, the skills and contents indicated by BNCC were analyzed from an interpretive research methodology view and under the dialogic perspective for discourse analysis developed by the Bakhtin Circle. (shrink)